Setting description

Taxel_therapies more effective in the TEfus+ biomarker signature

Simulations setting

PFS distributions


Treatment effects

By subgroup:

subtype var Other Hormone_therapies Taxel_therapies Carboplatin Niraparib
—- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
—+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
–+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
-+– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
-++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
+— param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+–+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
+-+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
++– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
+++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1


By signature:

signature var Other Hormone_therapies Taxel_therapies Carboplatin Niraparib
all param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.075, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 13.1, median = 9.4 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1.49, hr = 0.66 af = 1, hr = 1 af = 1, hr = 1
TP53- & AR- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.075, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 13.1, median = 9.4 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1.49, hr = 0.66 af = 1, hr = 1 af = 1, hr = 1
TP53+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.075, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 13.1, median = 9.4 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1.49, hr = 0.66 af = 1, hr = 1 af = 1, hr = 1
DRD+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.075, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 13.1, median = 9.4 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1.49, hr = 0.66 af = 1, hr = 1 af = 1, hr = 1
TEfus+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1

Errors and power


graduation (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 5 21 1 1
TP53- & AR- 29 115 9 9
TP53+ 1 31 3 2
DRD+ 2 20 1 0
TEfus+ 0 308 0 1
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.010 0.042 0.002 0.002
TP53- & AR- 0.058 0.230 0.018 0.018
TP53+ 0.002 0.062 0.006 0.004
DRD+ 0.004 0.040 0.002 0.000
TEfus+ 0.000 0.616 0.000 0.002
futility (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 18 0 0 4
TP53- & AR- 259 11 205 236
TP53+ 70 3 61 75
DRD+ 45 0 48 74
TEfus+ 207 0 228 215
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.036 0.000 0.000 0.008
TP53- & AR- 0.518 0.022 0.410 0.472
TP53+ 0.140 0.006 0.122 0.150
DRD+ 0.090 0.000 0.096 0.148
TEfus+ 0.414 0.000 0.456 0.430
max sample size (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0 0 0 0
TP53- & AR- 18 11 19 11
TP53+ 7 26 8 8
DRD+ 0 0 0 0
TEfus+ 2 21 2 2
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.000 0.000 0.000 0.000
TP53- & AR- 0.036 0.022 0.038 0.022
TP53+ 0.014 0.052 0.016 0.016
DRD+ 0.000 0.000 0.000 0.000
TEfus+ 0.004 0.042 0.004 0.004


Errors & power

The overall error was 0.22.
The corresponding errors separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.072             0.112             0.028             0.026 

The overall power was 0.616.
The corresponding power separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.000             0.616             0.000             0.000 

Median results at the end of the trial

By signature:
signature var Carboplatin Control Hormone_therapies Niraparib Taxel_therapies
all graduation 1 0 5 1 21
futility 0 0 18 4 0
max_n 0 0 0 0 0
n 180 (119, 253) 432 (394, 467) 170 (108, 250) 173 (113, 239) 187 (104, 269)
n_unique 168 (108, 237) 399 (364, 430) 157 (99, 231) 160 (102, 221) 171 (94, 251)
time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
time_stop 11 (11, 11) NA (NA, NA) 7 (3, 29) 18 (9, 35) 6 (5, 15)
post_p 0.07 (0, 0.39) NA (NA, NA) 0.06 (0, 0.37) 0.05 (0, 0.38) 1 (0.91, 1)
rate 0.112 (0.101, 0.126) 0.096 (0.089, 0.103) 0.113 (0.102, 0.128) 0.113 (0.101, 0.128) 0.067 (0.057, 0.083)
DRD+ graduation 1 0 2 0 20
futility 48 0 45 74 0
max_n 0 0 0 0 0
n 59 (38, 84) 117 (100, 133) 42 (25, 66) 55 (35, 82) 42 (20, 74)
n_unique 54 (35, 79) 107 (90, 122) 38 (22, 61) 51 (31, 76) 38 (18, 68)
time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (28, 36) 36 (36, 36)
time_stop 25 (14, 35) NA (NA, NA) 28 (19, 34) 24 (16, 34) 22 (18, 27)
post_p 0.13 (0.02, 0.56) NA (NA, NA) 0.18 (0.02, 0.62) 0.12 (0.01, 0.49) 0.94 (0.54, 1)
rate 0.113 (0.095, 0.138) 0.091 (0.078, 0.105) 0.113 (0.089, 0.147) 0.117 (0.095, 0.144) 0.064 (0.048, 0.093)
TEfus+ graduation 0 0 0 1 308
futility 228 0 207 215 0
max_n 2 0 2 2 21
n 59 (32, 97) 163 (143, 183) 51 (27, 94) 54 (29, 101) 72 (26, 141)
n_unique 54 (29, 88) 150 (130, 169) 46 (24, 87) 49 (27, 92) 65 (25, 128)
time_trial 36 (20, 36) 36 (36, 36) 36 (19, 36) 36 (19, 36) 24 (10, 36)
time_stop 26 (17, 34) NA (NA, NA) 25 (16, 34) 24 (16, 34) 15 (9, 29)
post_p 0.01 (0, 0.15) NA (NA, NA) 0.02 (0, 0.18) 0.02 (0, 0.15) 1 (1, 1)
rate 0.114 (0.095, 0.14) 0.074 (0.065, 0.086) 0.115 (0.095, 0.145) 0.115 (0.095, 0.143) 0.036 (0.029, 0.044)
TP53- & AR- graduation 9 0 29 9 115
futility 205 0 259 236 11
max_n 19 0 18 11 11
n 69 (27, 132) 177 (153, 201) 61 (26, 130) 64 (27, 117) 60 (26, 119)
n_unique 64 (24, 123) 165 (141, 188) 57 (25, 123) 58 (24, 110) 54 (24, 112)
time_trial 36 (16, 36) 36 (36, 36) 28 (9, 36) 36 (15, 36) 36 (14, 36)
time_stop 22 (13, 33) NA (NA, NA) 15 (7, 30) 22 (13, 33) 16 (10, 28)
post_p 0.26 (0.03, 0.72) NA (NA, NA) 0.25 (0.04, 0.73) 0.22 (0.03, 0.69) 0.94 (0.48, 1)
rate 0.113 (0.096, 0.144) 0.101 (0.091, 0.114) 0.115 (0.096, 0.142) 0.117 (0.098, 0.147) 0.078 (0.058, 0.103)
TP53+ graduation 3 0 1 2 31
futility 61 0 70 75 3
max_n 8 0 7 8 26
n 81 (45, 118) 194 (172, 216) 79 (36, 116) 79 (40, 116) 90 (41, 137)
n_unique 74 (41, 108) 178 (156, 199) 72 (34, 108) 73 (36, 108) 83 (38, 128)
time_trial 36 (31, 36) 36 (36, 36) 36 (28, 36) 36 (24, 36) 36 (36, 36)
time_stop 22 (13, 33) NA (NA, NA) 22 (10, 33) 21 (12, 32) 10 (7, 20)
post_p 0.11 (0.01, 0.46) NA (NA, NA) 0.1 (0.01, 0.47) 0.1 (0.01, 0.48) 1 (0.84, 1)
rate 0.114 (0.097, 0.136) 0.093 (0.083, 0.104) 0.114 (0.098, 0.138) 0.115 (0.097, 0.138) 0.062 (0.049, 0.079)


By subgroup combinations:
subtype var Carboplatin Control Hormone_therapies Niraparib Taxel_therapies
—- graduation 215 0 299 247 144
futility 0 0 0 0 0
max_n 19 0 18 11 11
n 38 (9, 90) 113 (93, 134) 39 (17, 99) 32 (10, 84) 31 (10, 82)
n_unique 36 (8, 86) 105 (85, 126) 37 (17, 94) 30 (9, 78) 29 (9, 77)
post_p 0.47 (0.09, 0.89) NA (NA, NA) 0.47 (0.11, 0.89) 0.42 (0.09, 0.89) 0.43 (0.09, 0.88)
rate 0.116 (0.093, 0.184) 0.112 (0.099, 0.129) 0.116 (0.094, 0.153) 0.119 (0.093, 0.18) 0.116 (0.091, 0.18)
—+ graduation 333 0 368 350 364
futility 0 0 0 0 0
max_n 20 0 19 12 31
n 6 (2, 17) 21 (14, 28) 6 (2, 16) 5 (2, 17) 8 (3, 22)
n_unique 5 (1, 16) 19 (12, 26) 5 (2, 14) 5 (1, 15) 7 (2, 21)
post_p 0.26 (0.11, 0.55) NA (NA, NA) 0.27 (0.09, 0.55) 0.28 (0.1, 0.57) 0.92 (0.58, 1)
rate 0.127 (0.078, 0.356) 0.074 (0.05, 0.111) 0.127 (0.076, 0.297) 0.134 (0.08, 0.381) 0.036 (0.02, 0.07)
–+- graduation 65 0 85 78 54
futility 0 0 0 0 0
max_n 8 0 7 8 26
n 24 (6, 52) 63 (50, 77) 25 (8, 59) 24 (7, 53) 22 (7, 53)
n_unique 22 (6, 50) 58 (44, 72) 24 (8, 55) 23 (6, 49) 21 (6, 49)
post_p 0.44 (0.11, 0.87) NA (NA, NA) 0.44 (0.09, 0.89) 0.46 (0.12, 0.86) 0.48 (0.13, 0.88)
rate 0.122 (0.091, 0.235) 0.114 (0.094, 0.14) 0.117 (0.093, 0.196) 0.121 (0.089, 0.212) 0.118 (0.087, 0.193)
–++ graduation 261 0 247 251 330
futility 0 0 0 0 0
max_n 9 0 9 8 43
n 11 (3, 32) 47 (36, 57) 10 (4, 31) 10 (3, 29) 22 (9, 50)
n_unique 10 (3, 30) 43 (33, 54) 9 (3, 30) 9 (3, 27) 21 (8, 46)
post_p 0.21 (0.05, 0.5) NA (NA, NA) 0.18 (0.04, 0.44) 0.19 (0.06, 0.49) 0.99 (0.84, 1)
rate 0.118 (0.078, 0.25) 0.075 (0.058, 0.096) 0.123 (0.084, 0.241) 0.123 (0.079, 0.258) 0.036 (0.025, 0.052)
-+– graduation 235 0 320 269 158
futility 0 0 0 0 0
max_n 19 0 18 11 11
n 10 (3, 22) 21 (14, 28) 5 (1, 16) 9 (3, 22) 6 (1, 18)
n_unique 9 (3, 21) 19 (13, 26) 4 (1, 15) 8 (2, 20) 5 (1, 16)
post_p 0.45 (0.17, 0.84) NA (NA, NA) 0.48 (0.21, 0.83) 0.43 (0.17, 0.85) 0.48 (0.16, 0.84)
rate 0.125 (0.081, 0.289) 0.113 (0.084, 0.16) 0.125 (0.071, 0.36) 0.128 (0.079, 0.307) 0.122 (0.07, 0.332)
-+-+ graduation 339 0 381 359 366
futility 0 0 0 0 0
max_n 20 0 19 12 31
n 8 (3, 19) 21 (14, 29) 5 (1, 16) 7 (2, 19) 5 (1, 20)
n_unique 8 (3, 18) 19 (12, 26) 4 (1, 15) 7 (2, 17) 5 (1, 19)
post_p 0.26 (0.09, 0.59) NA (NA, NA) 0.3 (0.11, 0.6) 0.25 (0.1, 0.53) 0.88 (0.51, 0.99)
rate 0.119 (0.076, 0.255) 0.076 (0.053, 0.111) 0.131 (0.073, 0.431) 0.125 (0.082, 0.336) 0.036 (0.013, 0.082)
-++- graduation 98 0 121 123 71
futility 0 0 0 0 0
max_n 8 0 7 7 26
n 6 (2, 13) 12 (7, 17) 4 (1, 10) 5 (2, 12) 4 (1, 10)
n_unique 5 (2, 12) 11 (6, 16) 4 (1, 9) 5 (2, 12) 3 (1, 9)
post_p 0.46 (0.21, 0.82) NA (NA, NA) 0.46 (0.23, 0.83) 0.44 (0.21, 0.8) 0.45 (0.23, 0.79)
rate 0.125 (0.071, 0.343) 0.114 (0.073, 0.17) 0.125 (0.064, 0.386) 0.135 (0.073, 0.358) 0.132 (0.068, 0.396)
-+++ graduation 272 0 263 264 332
futility 0 0 0 0 0
max_n 9 0 9 8 43
n 5 (2, 12) 13 (8, 18) 4 (1, 11) 5 (2, 13) 3 (0, 11)
n_unique 5 (2, 11) 11 (7, 16) 4 (1, 10) 4 (2, 12) 3 (0, 10)
post_p 0.32 (0.14, 0.62) NA (NA, NA) 0.35 (0.17, 0.61) 0.31 (0.13, 0.63) 0.78 (0.41, 0.96)
rate 0.132 (0.071, 0.326) 0.074 (0.045, 0.123) 0.128 (0.07, 0.396) 0.131 (0.071, 0.345) 0.042 (0, 0.126)
+— graduation 1 0 23 5 21
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 8 (3, 17) 20 (14, 27) 9 (2, 18) 8 (2, 17) 10 (3, 20)
n_unique 7 (2, 16) 18 (12, 25) 8 (2, 16) 7 (2, 15) 10 (3, 19)
post_p 0.47 (0.19, 0.86) NA (NA, NA) 0.43 (0.18, 0.84) 0.48 (0.19, 0.82) 0.46 (0.16, 0.84)
rate 0.121 (0.074, 0.308) 0.115 (0.082, 0.157) 0.128 (0.078, 0.342) 0.12 (0.073, 0.323) 0.124 (0.081, 0.27)
+–+ graduation 229 0 221 218 324
futility 0 0 0 0 0
max_n 2 0 2 2 21
n 5 (2, 13) 17 (12, 24) 5 (2, 14) 5 (2, 13) 8 (3, 18)
n_unique 4 (1, 12) 16 (11, 22) 4 (2, 13) 4 (1, 12) 7 (2, 17)
post_p 0.3 (0.12, 0.58) NA (NA, NA) 0.29 (0.14, 0.55) 0.31 (0.14, 0.62) 0.88 (0.58, 0.99)
rate 0.131 (0.071, 0.359) 0.075 (0.046, 0.11) 0.128 (0.078, 0.374) 0.128 (0.069, 0.365) 0.038 (0.02, 0.072)
+-+- graduation 65 0 85 78 54
futility 0 0 0 0 0
max_n 8 0 7 8 26
n 6 (2, 15) 16 (11, 22) 6 (2, 15) 6 (2, 15) 8 (3, 17)
n_unique 6 (2, 14) 15 (10, 20) 6 (1, 14) 6 (2, 14) 7 (2, 15)
post_p 0.45 (0.19, 0.81) NA (NA, NA) 0.45 (0.19, 0.83) 0.45 (0.2, 0.82) 0.48 (0.17, 0.84)
rate 0.13 (0.077, 0.553) 0.114 (0.078, 0.164) 0.128 (0.073, 0.391) 0.129 (0.073, 0.432) 0.124 (0.075, 0.294)
+-++ graduation 261 0 247 251 330
futility 0 0 0 0 0
max_n 9 0 9 8 43
n 5 (2, 13) 17 (12, 24) 5 (2, 14) 5 (2, 13) 7 (2, 19)
n_unique 5 (1, 12) 16 (10, 22) 5 (1, 12) 4 (1, 12) 7 (2, 17)
post_p 0.3 (0.12, 0.55) NA (NA, NA) 0.27 (0.13, 0.58) 0.3 (0.12, 0.59) 0.89 (0.56, 0.99)
rate 0.133 (0.074, 0.382) 0.076 (0.049, 0.113) 0.133 (0.075, 0.358) 0.133 (0.065, 0.375) 0.037 (0.016, 0.074)
++– graduation 50 0 67 77 41
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 6 (2, 13) 11 (7, 17) 5 (1, 11) 5 (2, 12) 4 (1, 10)
n_unique 6 (2, 12) 11 (6, 16) 4 (1, 10) 5 (2, 11) 4 (1, 9)
post_p 0.46 (0.2, 0.84) NA (NA, NA) 0.48 (0.23, 0.82) 0.43 (0.21, 0.82) 0.44 (0.22, 0.8)
rate 0.128 (0.071, 0.36) 0.114 (0.071, 0.175) 0.125 (0.058, 0.41) 0.133 (0.074, 0.374) 0.13 (0.066, 0.53)
++-+ graduation 243 0 238 246 327
futility 0 0 0 0 0
max_n 2 0 2 2 21
n 5 (2, 12) 12 (8, 18) 4 (1, 11) 5 (2, 12) 3 (0, 11)
n_unique 5 (1, 11) 11 (7, 16) 3 (1, 9) 4 (2, 11) 3 (0, 10)
post_p 0.32 (0.14, 0.63) NA (NA, NA) 0.34 (0.16, 0.64) 0.31 (0.13, 0.61) 0.79 (0.44, 0.96)
rate 0.129 (0.072, 0.375) 0.074 (0.043, 0.125) 0.132 (0.067, 0.539) 0.136 (0.074, 0.359) 0.04 (0.007, 0.105)
+++- graduation 98 0 121 123 71
futility 0 0 0 0 0
max_n 8 0 7 7 26
n 6 (2, 13) 12 (7, 17) 4 (1, 11) 5 (2, 12) 4 (1, 10)
n_unique 5 (2, 12) 11 (6, 16) 4 (1, 10) 5 (2, 12) 4 (1, 9)
post_p 0.48 (0.22, 0.83) NA (NA, NA) 0.44 (0.22, 0.8) 0.43 (0.2, 0.8) 0.45 (0.2, 0.79)
rate 0.122 (0.075, 0.355) 0.114 (0.07, 0.184) 0.135 (0.069, 0.454) 0.133 (0.075, 0.462) 0.133 (0.067, 0.418)
++++ graduation 272 0 263 264 332
futility 0 0 0 0 0
max_n 9 0 9 8 43
n 5 (2, 12) 12 (8, 18) 4 (1, 11) 5 (2, 12) 3 (0, 11)
n_unique 5 (2, 11) 11 (7, 17) 4 (1, 10) 4 (2, 11) 3 (0, 10)
post_p 0.32 (0.14, 0.63) NA (NA, NA) 0.35 (0.17, 0.68) 0.33 (0.15, 0.7) 0.81 (0.47, 0.96)
rate 0.13 (0.071, 0.36) 0.079 (0.047, 0.131) 0.13 (0.063, 0.393) 0.126 (0.069, 0.317) 0.036 (0, 0.111)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates


Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:
signature var Hormone_therapies Taxel_therapies Carboplatin Niraparib
all count 5 21 1 1
time_stop 6 (4, 8) 6 (5, 15) 11 (11, 11) 7 (7, 7)
n_trt 31 (28, 50) 38 (29, 75) 58 (58, 58) 34 (34, 34)
n_control 64 (50, 95) 71 (54, 158) 114 (114, 114) 64 (64, 64)
post_p 0.92 (0.9, 0.98) 0.98 (0.92, 1) 0.98 (0.98, 0.98) 0.94 (0.94, 0.94)
order 1 (1, 2.6) 1 (1, 2) 1 (1, 1) 1 (1, 1)
TP53- & AR- count 29 115 9 9
time_stop 10 (6, 14) 16 (10, 30) 13 (9, 19) 12 (9, 13)
n_trt 30 (25, 50) 34 (25, 68) 28 (25, 53) 28 (27, 36)
n_control 36 (25, 60) 68 (40, 136) 55 (47, 85) 49 (40, 61)
post_p 0.9 (0.86, 0.98) 0.96 (0.88, 1) 0.9 (0.89, 0.95) 0.93 (0.87, 0.97)
order 1 (1, 1) 1 (1, 2) 1 (1, 2.2) 1 (1, 2)
TP53+ count 1 31 3 2
time_stop 8 (8, 8) 10 (8, 21) 12 (11, 21) 10 (8, 12)
n_trt 26 (26, 26) 34 (26, 64) 31 (26, 37) 32 (30, 33)
n_control 33 (33, 33) 52 (31, 122) 62 (48, 108) 46 (36, 56)
post_p 0.88 (0.88, 0.88) 0.99 (0.94, 1) 0.93 (0.89, 0.97) 0.97 (0.95, 0.99)
order 1 (1, 1) 1 (1, 2) 2 (1.2, 2) 1.5 (1.1, 1.9)
DRD+ count 2 20 1
time_stop 18 (14, 21) 22 (18, 27) 10 (10, 10)
n_trt 28 (26, 30) 30 (26, 42) 30 (30, 30)
n_control 46 (36, 55) 61 (46, 87) 27 (27, 27)
post_p 0.92 (0.91, 0.93) 0.98 (0.93, 1) 0.98 (0.98, 0.98)
order 2.5 (2.1, 2.9) 2 (1, 3) 1 (1, 1)
TEfus+ count 308 1
time_stop 15 (9, 29) 12 (12, 12)
n_trt 43 (26, 105) 25 (25, 25)
n_control 59 (33, 123) 49 (49, 49)
post_p 1 (0.95, 1) 0.96 (0.96, 0.96)
order 1 (1, 2) 1 (1, 1)
Futility:
signature var Hormone_therapies Niraparib Taxel_therapies Carboplatin
all count 18 4
time_stop 10 (3, 29) 26 (14, 35)
n_trt 56 (27, 106) 94 (64, 133)
n_control 104 (35, 384) 286 (153, 422)
post_p 0.02 (0, 0.23) 0 (0, 0.01)
order 2 (1, 6) 4.5 (1.3, 7)
TP53- & AR- count 259 236 11 205
time_stop 17 (8, 31) 22 (14, 33) 17 (13, 22) 22 (14, 33)
n_trt 39 (25, 86) 39 (25, 90) 29 (27, 43) 35 (25, 98)
n_control 74 (33, 145) 104 (56, 162) 68 (61, 107) 102 (61, 166)
post_p 0.14 (0.04, 0.26) 0.12 (0.03, 0.24) 0.19 (0.09, 0.23) 0.13 (0.03, 0.26)
order 1 (1, 4) 2 (1, 4) 1 (1, 2) 2 (1, 4)
TP53+ count 70 75 3 61
time_stop 22 (10, 33) 22 (12, 32) 10 (7, 16) 22 (14, 33)
n_trt 42 (26, 68) 38 (26, 61) 28 (26, 46) 44 (27, 83)
n_control 109 (47, 171) 104 (56, 175) 60 (31, 86) 112 (66, 184)
post_p 0.03 (0, 0.22) 0.02 (0, 0.12) 0.19 (0.06, 0.22) 0.02 (0, 0.08)
order 2 (1, 5) 2 (1, 5) 1 (1, 1) 2 (1, 5)
DRD+ count 45 74 48
time_stop 30 (19, 34) 24 (16, 34) 26 (14, 35)
n_trt 31 (25, 45) 36 (26, 52) 38 (26, 59)
n_control 86 (52, 110) 74 (44, 106) 84 (42, 113)
post_p 0.04 (0, 0.17) 0.02 (0, 0.1) 0.03 (0, 0.11)
order 3 (1.4, 6) 3.5 (1, 6) 3 (1, 6)
TEfus+ count 207 215 228
time_stop 25 (16, 34) 24 (16, 34) 26 (17, 34)
n_trt 38 (26, 67) 43 (26, 76) 48 (27, 76)
n_control 107 (62, 152) 105 (62, 155) 112 (62, 159)
post_p 0.01 (0, 0.08) 0.01 (0, 0.07) 0.01 (0, 0.06)
order 3 (1, 5) 3 (1, 5) 3 (1, 5)


By subgroup combinations

Graduation:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all Carboplatin count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
time 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11)
n 19 (19, 19) 3 (3, 3) 15 (15, 15) 3 (3, 3) 4 (4, 4) 4 (4, 4) 0 (0, 0) 1 (1, 1) 2 (2, 2) 0 (0, 0) 2 (2, 2) 2 (2, 2) 0 (0, 0) 2 (2, 2) 1 (1, 1) 0 (0, 0)
post_p 0.78 (0.78, 0.78) 0.68 (0.68, 0.68) 0.65 (0.65, 0.65) 0.69 (0.69, 0.69) 0.5 (0.5, 0.5) 0.5 (0.5, 0.5) NA (NA, NA) 0.64 (0.64, 0.64) 0.51 (0.51, 0.51) NA (NA, NA) 0.59 (0.59, 0.59) 0.55 (0.55, 0.55) NA (NA, NA) 0.71 (0.71, 0.71) 0.56 (0.56, 0.56) NA (NA, NA)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.079 (0.079, 0.079) 0 (0, 0) 0.079 (0.079, 0.079) 0 (0, 0) 0.067 (0.067, 0.067) 0.053 (0.053, 0.053) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA)
Hormone_therapies count 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5
time 6 (4, 8) 6 (4, 8) 6 (4, 8) 6 (4, 8) 6 (4, 8) 6 (4, 8) 6 (4, 8) 6 (4, 8) 6 (4, 8) 6 (4, 8) 6 (4, 8) 6 (4, 8) 6 (4, 8) 6 (4, 8) 6 (4, 8) 6 (4, 8)
n 17 (10, 23) 2 (0, 3) 7 (4, 9) 3 (1, 5) 0 (0, 0) 0 (0, 1) 0 (0, 1) 0 (0, 2) 2 (0, 4) 1 (0, 4) 1 (0, 2) 1 (0, 3) 0 (0, 1) 0 (0, 3) 0 (0, 1) 0 (0, 0)
post_p 0.69 (0.59, 0.87) 0.62 (0.61, 0.68) 0.72 (0.63, 0.87) 0.56 (0.52, 0.7) NA (NA, NA) 0.61 (0.61, 0.61) NA (NA, NA) NA (NA, NA) 0.58 (0.52, 0.63) 0.65 (0.64, 0.67) 0.57 (0.53, 0.6) 0.56 (0.55, 0.62) 0.63 (0.61, 0.64) 0.55 (0.55, 0.55) 0.58 (0.58, 0.58) NA (NA, NA)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.059 (0.028, 0.091) 0 (0, 0) 0 (0, 0.083) 0 (0, 0.095) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0.128 (0.128, 0.128) 0 (0, 0) 0 (0, 0) 0 (0, 0.092) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA)
Niraparib count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
time 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7)
n 7 (7, 7) 0 (0, 0) 4 (4, 4) 1 (1, 1) 3 (3, 3) 3 (3, 3) 0 (0, 0) 4 (4, 4) 0 (0, 0) 0 (0, 0) 1 (1, 1) 5 (5, 5) 3 (3, 3) 0 (0, 0) 1 (1, 1) 2 (2, 2)
post_p 0.62 (0.62, 0.62) NA (NA, NA) 0.71 (0.71, 0.71) 0.51 (0.51, 0.51) 0.56 (0.56, 0.56) 0.52 (0.52, 0.52) NA (NA, NA) 0.89 (0.89, 0.89) NA (NA, NA) NA (NA, NA) 0.53 (0.53, 0.53) 0.71 (0.71, 0.71) 0.6 (0.6, 0.6) NA (NA, NA) 0.52 (0.52, 0.52) NA (NA, NA)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.058 (0.058, 0.058) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0.112 (0.112, 0.112) 0.081 (0.081, 0.081) NA (NA, NA) 0.05 (0.05, 0.05) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0.105 (0.105, 0.105) NA (NA, NA) 0 (0, 0) 0 (0, 0)
Taxel_therapies count 21 21 21 21 21 21 21 21 21 21 21 21 21 21 21 21
time 6 (5, 15) 6 (5, 15) 6 (5, 15) 6 (5, 15) 6 (5, 15) 6 (5, 15) 6 (5, 15) 6 (5, 15) 6 (5, 15) 6 (5, 15) 6 (5, 15) 6 (5, 15) 6 (5, 15) 6 (5, 15) 6 (5, 15) 6 (5, 15)
n 9 (5, 16) 3 (1, 8) 6 (2, 12) 9 (5, 13) 0 (0, 2) 0 (0, 2) 0 (0, 2) 0 (0, 2) 3 (0, 8) 3 (1, 5) 3 (0, 6) 2 (0, 3) 0 (0, 3) 0 (0, 1) 0 (0, 2) 0 (0, 2)
post_p 0.65 (0.54, 0.86) 0.64 (0.52, 0.87) 0.62 (0.54, 0.74) 0.78 (0.61, 0.96) 0.54 (0.5, 0.62) 0.59 (0.52, 0.76) 0.56 (0.51, 0.63) 0.62 (0.55, 0.72) 0.59 (0.51, 0.75) 0.66 (0.51, 0.84) 0.6 (0.5, 0.76) 0.57 (0.53, 0.74) 0.58 (0.51, 0.62) 0.69 (0.55, 0.73) 0.54 (0.52, 0.55) 0.56 (0.52, 0.78)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.08 (0, 0.121) 0 (0, 0.126) 0.082 (0, 0.142) 0 (0, 0.037) 0 (0, 0.01) 0 (0, 0.01) 0 (0, 0.099) 0 (0, 0.071) 0.05 (0, 0.112) 0 (0, 0.012) 0.048 (0, 0.122) 0 (0, 0.056) 0 (0, 0.118) 0 (0, 0.051) 0 (0, 0.148) 0 (0, 0.015)
DRD+ Carboplatin count 1 1 1 1 1 1 1 1
time 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10)
n 8 (8, 8) 5 (5, 5) 4 (4, 4) 0 (0, 0) 3 (3, 3) 2 (2, 2) 4 (4, 4) 4 (4, 4)
post_p 0.83 (0.83, 0.83) 0.98 (0.98, 0.98) 0.73 (0.73, 0.73) NA (NA, NA) 0.53 (0.53, 0.53) 0.57 (0.57, 0.57) 0.58 (0.58, 0.58) 0.63 (0.63, 0.63)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.049 (0.049, 0.049) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0.149 (0.149, 0.149) 0.089 (0.089, 0.089) 0.056 (0.056, 0.056) 0 (0, 0)
Hormone_therapies count 2 2 2 2 2 2 2 2
time 18 (14, 21) 18 (14, 21) 18 (14, 21) 18 (14, 21) 18 (14, 21) 18 (14, 21) 18 (14, 21) 18 (14, 21)
n 5 (3, 7) 4 (3, 5) 4 (2, 6) 2 (2, 2) 3 (2, 4) 2 (1, 4) 3 (2, 4) 4 (3, 6)
post_p 0.65 (0.58, 0.72) 0.57 (0.54, 0.6) 0.66 (0.56, 0.77) 0.51 (0.51, 0.51) 0.59 (0.59, 0.59) 0.52 (0.52, 0.52) 0.8 (0.7, 0.9) 0.63 (0.53, 0.73)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.097 (0.084, 0.111) 0.05 (0.01, 0.09) 0.046 (0.009, 0.083) 0.106 (0.084, 0.128) 0.042 (0.008, 0.076) 0.076 (0.076, 0.076) 0.047 (0.009, 0.084) 0.059 (0.031, 0.087)
Taxel_therapies count 20 20 20 20 20 20 20 20
time 22 (18, 27) 22 (18, 27) 22 (18, 27) 22 (18, 27) 22 (18, 27) 22 (18, 27) 22 (18, 27) 22 (18, 27)
n 4 (2, 12) 4 (2, 10) 3 (1, 5) 4 (0, 5) 4 (1, 7) 3 (1, 5) 3 (0, 6) 3 (0, 6)
post_p 0.71 (0.52, 0.83) 0.83 (0.71, 0.95) 0.66 (0.52, 0.79) 0.7 (0.55, 0.91) 0.67 (0.59, 0.8) 0.71 (0.54, 0.88) 0.66 (0.53, 0.76) 0.77 (0.54, 0.91)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.079 (0.026, 0.114) 0.023 (0, 0.055) 0.076 (0, 0.128) 0.028 (0, 0.096) 0.062 (0, 0.111) 0.026 (0, 0.082) 0.081 (0.013, 0.162) 0.035 (0, 0.09)
TEfus+ Niraparib count 1 1 1 1 1 1 1 1
time 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12)
n 2 (2, 2) 2 (2, 2) 10 (10, 10) 2 (2, 2) 2 (2, 2) 2 (2, 2) 2 (2, 2) 3 (3, 3)
post_p 0.67 (0.67, 0.67) 0.57 (0.57, 0.57) 0.71 (0.71, 0.71) 0.51 (0.51, 0.51) 0.6 (0.6, 0.6) 0.57 (0.57, 0.57) 0.77 (0.77, 0.77) 0.72 (0.72, 0.72)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0 (0, 0) 0 (0, 0) 0.065 (0.065, 0.065) 0.053 (0.053, 0.053) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
Taxel_therapies count 308 308 308 308 308 308 308 308
time 15 (9, 29) 15 (9, 29) 15 (9, 29) 15 (9, 29) 15 (9, 29) 15 (9, 29) 15 (9, 29) 15 (9, 29)
n 7 (3, 16) 15 (8, 35) 3 (1, 12) 2 (0, 7) 6 (2, 13) 5 (2, 12) 2 (0, 7) 2 (0, 7)
post_p 0.78 (0.56, 0.97) 0.88 (0.73, 0.99) 0.72 (0.53, 0.92) 0.65 (0.52, 0.86) 0.75 (0.56, 0.93) 0.76 (0.55, 0.93) 0.66 (0.53, 0.86) 0.66 (0.52, 0.89)
r_prob 0.29 (0.29, 0.29) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.029 (0, 0.067) 0.033 (0.013, 0.054) 0 (0, 0.064) 0 (0, 0.081) 0.027 (0, 0.07) 0.03 (0, 0.071) 0 (0, 0.066) 0 (0, 0.071)
TP53- & AR- Carboplatin count 9 9 9 9
time 13 (9, 19) 13 (9, 19) 13 (9, 19) 13 (9, 19)
n 19 (15, 35) 2 (0, 4) 6 (2, 9) 4 (1, 12)
post_p 0.79 (0.75, 0.85) 0.6 (0.53, 0.66) 0.74 (0.53, 0.8) 0.72 (0.52, 0.83)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.074 (0.063, 0.103) 0.038 (0, 0.115) 0.063 (0.026, 0.175) 0.038 (0, 0.101)
Hormone_therapies count 29 29 29 29
time 10 (6, 14) 10 (6, 14) 10 (6, 14) 10 (6, 14)
n 25 (20, 38) 4 (1, 5) 1 (0, 4) 1 (0, 3)
post_p 0.86 (0.74, 0.94) 0.62 (0.52, 0.76) 0.59 (0.52, 0.84) 0.56 (0.51, 0.74)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0 (0, 0) 0 (0, 0)
rate 0.073 (0.056, 0.101) 0.017 (0, 0.087) 0 (0, 0.069) 0 (0, 0.097)
Niraparib count 9 9 9 9
time 12 (9, 13) 12 (9, 13) 12 (9, 13) 12 (9, 13)
n 17 (12, 23) 3 (0, 3) 5 (3, 6) 7 (2, 8)
post_p 0.76 (0.71, 0.91) 0.58 (0.53, 0.67) 0.72 (0.54, 0.83) 0.72 (0.64, 0.86)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.065 (0.024, 0.1) 0 (0, 0.066) 0.067 (0, 0.076) 0.051 (0, 0.08)
Taxel_therapies count 115 115 115 115
time 16 (10, 30) 16 (10, 30) 16 (10, 30) 16 (10, 30)
n 21 (15, 47) 6 (3, 12) 3 (0, 7) 3 (1, 10)
post_p 0.8 (0.72, 0.91) 0.8 (0.61, 0.95) 0.59 (0.51, 0.81) 0.7 (0.54, 0.95)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0)
rate 0.08 (0.055, 0.103) 0.028 (0, 0.06) 0.077 (0, 0.14) 0.014 (0, 0.071)
TP53+ Carboplatin count 3 3 3 3 3 3 3 3
time 12 (11, 21) 12 (11, 21) 12 (11, 21) 12 (11, 21) 12 (11, 21) 12 (11, 21) 12 (11, 21) 12 (11, 21)
n 14 (11, 14) 5 (2, 10) 1 (0, 3) 2 (0, 3) 4 (2, 4) 0 (0, 2) 3 (1, 5) 3 (2, 4)
post_p 0.85 (0.75, 0.9) 0.55 (0.51, 0.79) 0.73 (0.66, 0.81) 0.73 (0.69, 0.77) 0.51 (0.51, 0.59) 0.62 (0.62, 0.62) 0.57 (0.53, 0.58) 0.63 (0.62, 0.82)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.065 (0.047, 0.085) 0.036 (0.007, 0.076) 0.061 (0.012, 0.11) 0 (0, 0) 0.081 (0.016, 0.109) 0 (0, 0) 0.06 (0.012, 0.061) 0.067 (0.057, 0.1)
Hormone_therapies count 1 1 1 1 1 1 1 1
time 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8)
n 23 (23, 23) 2 (2, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 1 (1, 1) 0 (0, 0) 0 (0, 0)
post_p 0.89 (0.89, 0.89) 0.62 (0.62, 0.62) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
r_prob 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.052 (0.052, 0.052) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.402 (0.402, 0.402) NA (NA, NA) NA (NA, NA)
Niraparib count 2 2 2 2 2 2 2 2
time 10 (8, 12) 10 (8, 12) 10 (8, 12) 10 (8, 12) 10 (8, 12) 10 (8, 12) 10 (8, 12) 10 (8, 12)
n 12 (9, 14) 4 (4, 5) 3 (2, 4) 4 (2, 6) 1 (0, 2) 2 (2, 3) 4 (4, 4) 1 (1, 1)
post_p 0.9 (0.88, 0.93) 0.66 (0.56, 0.75) 0.65 (0.63, 0.67) 0.75 (0.74, 0.75) 0.61 (0.61, 0.61) 0.56 (0.54, 0.59) 0.7 (0.7, 0.7) 0.62 (0.54, 0.7)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.031 (0.006, 0.056) 0.042 (0.008, 0.076) 0.076 (0.015, 0.137) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.106 (0.085, 0.126) 0 (0, 0)
Taxel_therapies count 31 31 31 31 31 31 31 31
time 10 (8, 21) 10 (8, 21) 10 (8, 21) 10 (8, 21) 10 (8, 21) 10 (8, 21) 10 (8, 21) 10 (8, 21)
n 9 (5, 18) 12 (9, 18) 1 (0, 5) 1 (0, 3) 4 (1, 9) 5 (2, 10) 1 (0, 3) 1 (0, 4)
post_p 0.82 (0.71, 0.91) 0.87 (0.74, 0.98) 0.59 (0.51, 0.72) 0.64 (0.57, 0.77) 0.64 (0.53, 0.88) 0.7 (0.58, 0.92) 0.65 (0.53, 0.78) 0.56 (0.51, 0.79)
r_prob 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.048 (0, 0.086) 0.026 (0, 0.048) 0 (0, 0.102) 0 (0, 0.084) 0.068 (0, 0.141) 0.012 (0, 0.073) 0 (0, 0.101) 0 (0, 0.129)
Futility:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all Hormone_therapies count 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18
time 10 (3, 29) 10 (3, 29) 10 (3, 29) 10 (3, 29) 10 (3, 29) 10 (3, 29) 10 (3, 29) 10 (3, 29) 10 (3, 29) 10 (3, 29) 10 (3, 29) 10 (3, 29) 10 (3, 29) 10 (3, 29) 10 (3, 29) 10 (3, 29)
n 20 (13, 46) 3 (1, 5) 10 (6, 30) 4 (1, 5) 0 (0, 4) 0 (0, 3) 0 (0, 3) 1 (0, 3) 2 (0, 7) 2 (1, 5) 1 (0, 4) 1 (0, 5) 0 (0, 4) 0 (0, 7) 0 (0, 2) 0 (0, 3)
post_p 0.27 (0.09, 0.41) 0.35 (0.22, 0.42) 0.33 (0.21, 0.44) 0.32 (0.1, 0.46) 0.39 (0.2, 0.49) 0.29 (0.15, 0.44) 0.3 (0.21, 0.48) 0.4 (0.19, 0.49) 0.32 (0.15, 0.46) 0.32 (0.24, 0.43) 0.32 (0.23, 0.48) 0.33 (0.2, 0.46) 0.38 (0.15, 0.47) 0.36 (0.24, 0.4) 0.32 (0.21, 0.4) 0.37 (0.32, 0.46)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.135 (0.1, 0.191) 0.155 (0.03, 0.402) 0.126 (0.088, 0.214) 0.18 (0.088, 0.312) 0.197 (0.086, 0.449) 0.195 (0.11, 8.641) 0.184 (0.079, 0.243) 0.128 (0.072, 0.3) 0.266 (0.109, 0.956) 0.139 (0, 0.271) 0.191 (0.101, 1.29) 0.176 (0.009, 0.743) 0.174 (0.059, 0.561) 0.168 (0.063, 0.545) 0.339 (0.255, 1.021) 0.156 (0.057, 1.486)
Niraparib count 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4
time 26 (14, 35) 26 (14, 35) 26 (14, 35) 26 (14, 35) 26 (14, 35) 26 (14, 35) 26 (14, 35) 26 (14, 35) 26 (14, 35) 26 (14, 35) 26 (14, 35) 26 (14, 35) 26 (14, 35) 26 (14, 35) 26 (14, 35) 26 (14, 35)
n 19 (9, 30) 4 (1, 11) 12 (8, 18) 13 (6, 17) 4 (2, 6) 3 (2, 7) 5 (1, 8) 4 (1, 10) 2 (0, 6) 4 (2, 8) 2 (1, 6) 4 (2, 7) 3 (2, 7) 3 (2, 4) 3 (3, 5) 3 (2, 4)
post_p 0.41 (0.23, 0.47) 0.31 (0.11, 0.4) 0.25 (0.16, 0.4) 0.4 (0.28, 0.42) 0.35 (0.21, 0.49) 0.31 (0.25, 0.44) 0.43 (0.22, 0.44) 0.43 (0.27, 0.49) 0.42 (0.38, 0.46) 0.42 (0.27, 0.48) 0.31 (0.18, 0.46) 0.24 (0.16, 0.36) 0.19 (0.14, 0.3) 0.17 (0.13, 0.28) 0.39 (0.18, 0.39) 0.37 (0.19, 0.49)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.125 (0.118, 0.181) 0.127 (0.07, 0.155) 0.134 (0.123, 0.16) 0.102 (0.084, 0.186) 0.198 (0.11, 0.829) 0.129 (0.126, 0.135) 0.203 (0.141, 0.273) 0.103 (0.089, 0.381) 0.139 (0.092, 0.699) 0.1 (0.085, 0.147) 0.287 (0.163, 0.595) 0.182 (0.14, 1.748) 0.409 (0.195, 1.03) 0.194 (0.175, 0.201) 0.161 (0.142, 0.254) 0.181 (0.155, 0.391)
DRD+ Carboplatin count 48 48 48 48 48 48 48 48
time 26 (14, 35) 26 (14, 35) 26 (14, 35) 26 (14, 35) 26 (14, 35) 26 (14, 35) 26 (14, 35) 26 (14, 35)
n 6 (2, 14) 6 (3, 12) 3 (1, 7) 4 (2, 8) 3 (1, 9) 4 (2, 9) 3 (2, 8) 4 (1, 10)
post_p 0.36 (0.18, 0.49) 0.28 (0.1, 0.44) 0.34 (0.22, 0.47) 0.35 (0.14, 0.47) 0.35 (0.21, 0.48) 0.33 (0.15, 0.47) 0.38 (0.18, 0.48) 0.35 (0.18, 0.46)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.155 (0.098, 0.458) 0.119 (0.088, 0.269) 0.2 (0.115, 0.68) 0.127 (0.072, 0.343) 0.184 (0.109, 0.687) 0.148 (0.091, 0.385) 0.189 (0.099, 0.474) 0.136 (0.085, 0.371)
Hormone_therapies count 45 45 45 45 45 45 45 45
time 30 (19, 34) 30 (19, 34) 30 (19, 34) 30 (19, 34) 30 (19, 34) 30 (19, 34) 30 (19, 34) 30 (19, 34)
n 4 (1, 9) 5 (1, 14) 3 (1, 8) 3 (1, 9) 4 (2, 7) 3 (1, 7) 3 (1, 9) 4 (1, 9)
post_p 0.34 (0.16, 0.48) 0.28 (0.14, 0.46) 0.34 (0.19, 0.48) 0.32 (0.14, 0.43) 0.4 (0.24, 0.49) 0.37 (0.12, 0.46) 0.36 (0.21, 0.48) 0.35 (0.21, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.168 (0.114, 0.406) 0.143 (0.088, 0.37) 0.201 (0.106, 2.566) 0.165 (0.091, 0.806) 0.169 (0.1, 0.434) 0.159 (0.086, 0.619) 0.179 (0.11, 0.965) 0.139 (0.082, 0.626)
Niraparib count 74 74 74 74 74 74 74 74
time 24 (16, 34) 24 (16, 34) 24 (16, 34) 24 (16, 34) 24 (16, 34) 24 (16, 34) 24 (16, 34) 24 (16, 34)
n 6 (2, 12) 7 (3, 13) 3 (1, 8) 3 (1, 8) 3 (1, 8) 4 (1, 7) 3 (1, 7) 3 (1, 7)
post_p 0.36 (0.16, 0.48) 0.27 (0.13, 0.44) 0.35 (0.21, 0.46) 0.31 (0.15, 0.46) 0.35 (0.21, 0.47) 0.32 (0.16, 0.46) 0.37 (0.17, 0.47) 0.32 (0.14, 0.45)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.152 (0.107, 0.317) 0.131 (0.087, 0.39) 0.171 (0.097, 0.546) 0.157 (0.086, 0.492) 0.171 (0.113, 0.415) 0.159 (0.088, 0.393) 0.188 (0.106, 0.835) 0.165 (0.087, 0.543)
TEfus+ Carboplatin count 228 228 228 228 228 228 228 228
time 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34)
n 5 (2, 13) 8 (3, 24) 7 (3, 16) 4 (2, 11) 4 (1, 10) 4 (1, 9) 4 (2, 9) 4 (2, 9)
post_p 0.32 (0.14, 0.46) 0.24 (0.08, 0.48) 0.3 (0.11, 0.48) 0.35 (0.14, 0.47) 0.31 (0.15, 0.46) 0.3 (0.15, 0.44) 0.33 (0.15, 0.47) 0.32 (0.16, 0.47)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.137 (0.08, 0.388) 0.119 (0.079, 0.291) 0.122 (0.083, 0.268) 0.139 (0.087, 0.418) 0.144 (0.085, 0.514) 0.153 (0.085, 0.498) 0.148 (0.086, 0.45) 0.142 (0.084, 0.396)
Hormone_therapies count 207 207 207 207 207 207 207 207
time 25 (16, 34) 25 (16, 34) 25 (16, 34) 25 (16, 34) 25 (16, 34) 25 (16, 34) 25 (16, 34) 25 (16, 34)
n 5 (2, 11) 8 (4, 22) 4 (1, 12) 3 (1, 7) 4 (2, 11) 4 (1, 10) 3 (1, 7) 3 (1, 8)
post_p 0.28 (0.13, 0.45) 0.21 (0.06, 0.44) 0.32 (0.14, 0.48) 0.34 (0.17, 0.47) 0.32 (0.15, 0.47) 0.31 (0.14, 0.47) 0.34 (0.19, 0.48) 0.36 (0.19, 0.46)
r_prob 0.35 (0.35, 0.35) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.145 (0.082, 0.313) 0.125 (0.085, 0.267) 0.138 (0.084, 0.452) 0.155 (0.084, 0.509) 0.138 (0.085, 0.446) 0.141 (0.087, 0.551) 0.167 (0.086, 0.652) 0.147 (0.085, 0.491)
Niraparib count 215 215 215 215 215 215 215 215
time 24 (16, 34) 24 (16, 34) 24 (16, 34) 24 (16, 34) 24 (16, 34) 24 (16, 34) 24 (16, 34) 24 (16, 34)
n 4 (1, 14) 7 (3, 22) 6 (2, 15) 4 (2, 10) 4 (1, 10) 4 (1, 9) 4 (1, 8) 4 (2, 8)
post_p 0.3 (0.15, 0.44) 0.24 (0.08, 0.46) 0.3 (0.1, 0.47) 0.33 (0.16, 0.46) 0.33 (0.17, 0.47) 0.33 (0.16, 0.45) 0.33 (0.17, 0.46) 0.36 (0.2, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.142 (0.088, 0.568) 0.13 (0.082, 0.314) 0.133 (0.085, 0.349) 0.143 (0.087, 0.394) 0.138 (0.083, 0.393) 0.143 (0.083, 0.495) 0.158 (0.084, 0.506) 0.142 (0.081, 0.293)
TP53- & AR- Carboplatin count 205 205 205 205
time 22 (14, 33) 22 (14, 33) 22 (14, 33) 22 (14, 33)
n 17 (8, 65) 4 (2, 13) 6 (2, 16) 6 (3, 15)
post_p 0.33 (0.11, 0.48) 0.32 (0.13, 0.45) 0.37 (0.17, 0.48) 0.31 (0.12, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.131 (0.105, 0.198) 0.145 (0.091, 0.423) 0.145 (0.103, 0.402) 0.13 (0.083, 0.3)
Hormone_therapies count 259 259 259 259
time 17 (8, 31) 17 (8, 31) 17 (8, 31) 17 (8, 31)
n 25 (17, 65) 5 (2, 10) 3 (0, 8) 3 (0, 9)
post_p 0.34 (0.12, 0.47) 0.32 (0.14, 0.46) 0.38 (0.23, 0.48) 0.35 (0.16, 0.48)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0 (0, 0) 0 (0, 0)
rate 0.125 (0.105, 0.166) 0.137 (0.072, 0.325) 0.164 (0.092, 0.529) 0.148 (0.076, 0.563)
Niraparib count 236 236 236 236
time 22 (14, 33) 22 (14, 33) 22 (14, 33) 22 (14, 33)
n 22 (9, 58) 4 (1, 12) 6 (2, 14) 6 (2, 13)
post_p 0.36 (0.13, 0.47) 0.32 (0.14, 0.46) 0.38 (0.16, 0.49) 0.27 (0.1, 0.44)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.128 (0.106, 0.197) 0.141 (0.084, 0.418) 0.159 (0.104, 0.417) 0.148 (0.091, 0.378)
Taxel_therapies count 11 11 11 11
time 17 (13, 22) 17 (13, 22) 17 (13, 22) 17 (13, 22)
n 23 (13, 35) 5 (2, 9) 4 (0, 5) 2 (1, 4)
post_p 0.35 (0.24, 0.45) 0.32 (0.27, 0.41) 0.42 (0.24, 0.44) 0.44 (0.32, 0.47)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0)
rate 0.143 (0.107, 0.152) 0.114 (0.078, 0.312) 0.152 (0.094, 0.31) 0.125 (0.063, 0.521)
TP53+ Carboplatin count 61 61 61 61 61 61 61 61
time 22 (14, 33) 22 (14, 33) 22 (14, 33) 22 (14, 33) 22 (14, 33) 22 (14, 33) 22 (14, 33) 22 (14, 33)
n 12 (3, 35) 8 (4, 23) 3 (1, 9) 4 (1, 7) 3 (1, 8) 4 (1, 9) 3 (1, 8) 3 (1, 8)
post_p 0.3 (0.14, 0.48) 0.24 (0.08, 0.44) 0.33 (0.21, 0.48) 0.38 (0.18, 0.49) 0.36 (0.22, 0.48) 0.36 (0.18, 0.48) 0.38 (0.22, 0.47) 0.32 (0.16, 0.45)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.141 (0.111, 0.422) 0.126 (0.086, 0.263) 0.211 (0.107, 0.609) 0.152 (0.085, 0.39) 0.174 (0.103, 0.766) 0.14 (0.07, 0.698) 0.18 (0.111, 0.482) 0.176 (0.082, 0.597)
Hormone_therapies count 70 70 70 70 70 70 70 70
time 22 (10, 33) 22 (10, 33) 22 (10, 33) 22 (10, 33) 22 (10, 33) 22 (10, 33) 22 (10, 33) 22 (10, 33)
n 14 (6, 35) 8 (3, 14) 2 (0, 6) 2 (1, 8) 3 (1, 7) 3 (1, 10) 2 (0, 5) 2 (1, 6)
post_p 0.3 (0.1, 0.46) 0.24 (0.07, 0.45) 0.38 (0.18, 0.49) 0.34 (0.17, 0.48) 0.34 (0.15, 0.47) 0.33 (0.18, 0.48) 0.35 (0.26, 0.48) 0.36 (0.18, 0.48)
r_prob 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.129 (0.102, 0.242) 0.129 (0.089, 0.304) 0.176 (0.077, 0.6) 0.162 (0.089, 0.556) 0.197 (0.108, 0.892) 0.14 (0.083, 0.658) 0.213 (0.12, 0.666) 0.18 (0.042, 0.751)
Niraparib count 75 75 75 75 75 75 75 75
time 22 (12, 32) 22 (12, 32) 22 (12, 32) 22 (12, 32) 22 (12, 32) 22 (12, 32) 22 (12, 32) 22 (12, 32)
n 10 (5, 23) 5 (2, 16) 3 (1, 7) 4 (1, 8) 3 (1, 7) 3 (1, 8) 3 (1, 6) 3 (1, 7)
post_p 0.34 (0.11, 0.47) 0.32 (0.1, 0.47) 0.37 (0.19, 0.48) 0.3 (0.13, 0.45) 0.35 (0.23, 0.48) 0.35 (0.17, 0.46) 0.34 (0.2, 0.48) 0.34 (0.18, 0.48)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.135 (0.104, 0.244) 0.127 (0.08, 0.459) 0.197 (0.104, 0.479) 0.192 (0.089, 0.436) 0.185 (0.102, 0.915) 0.16 (0.086, 0.958) 0.205 (0.103, 0.982) 0.155 (0.076, 0.414)
Taxel_therapies count 3 3 3 3 3 3 3 3
time 10 (7, 16) 10 (7, 16) 10 (7, 16) 10 (7, 16) 10 (7, 16) 10 (7, 16) 10 (7, 16) 10 (7, 16)
n 11 (9, 17) 9 (8, 9) 2 (0, 3) 0 (0, 1) 6 (1, 6) 4 (3, 9) 0 (0, 2) 0 (0, 3)
post_p 0.4 (0.2, 0.44) 0.44 (0.24, 0.48) 0.32 (0.28, 0.36) 0.5 (0.5, 0.5) 0.14 (0.08, 0.19) 0.38 (0.23, 0.43) 0.49 (0.49, 0.49) 0.37 (0.37, 0.37)
r_prob 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.128 (0.118, 0.134) 0.085 (0.054, 0.09) 0.178 (0.036, 0.321) 0 (0, 0) 0.184 (0.143, 0.225) 0.082 (0.069, 0.153) 0.27 (0.27, 0.27) 0.129 (0.129, 0.129)